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Background: The effect of seed extract of Citrullus lanatus on lipid profile and histology of duodenum in Wistar rats was determined in the current study. The medicinal and nutritional importance of Citrullus lanatus has been emphasized in previous works and its disease preventive ability is being evaluated.
Methodology: A total of twenty-one male rats, divided into groups (n= 4). Group 1 served as control group fed normal feed, group 2 were administered 100mg/kg seed extract body weight, group 3 were administered 200mg/kg and group 4 were administered 400mg/kg for twenty-one days. At the end of the experiment, the rats were sacrificed by cervical dislocation, blood samples were centrifuged to obtain serum for biochemical determination of Triglycerides, Total cholesterol level, High-density lipoprotein and Low-density lipoprotein levels. The duodenum, jejunum and stomach were excised for histological studies.
Results: Results show that on administration of seed extract from the different doses there was no significant difference (p>0.05) in the high-density lipoprotein(HDL) when compared with control. Low-density lipoprotein (LDL reduced in the 200mg/kg group when compared to other doses and control group. Plasma triglycerides and total plasma cholesterol levels compared with the control had no difference. Histological analysis revealed no observable changes in the histology of experimental animals administered with seed extract when compared with control.
Conclusion: This study has demonstrated that long term administration of the seed extract of Citrullus lanatus will reduce LDL cholesterol and body weight.
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